SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells. One attractive hypothesis is that the X occupies a specific territory in the nucleus, facilitating spreading of the MSL complex Brain Res.
Additional student notes and teacher guide for School Assessed Coursework provided on request. Nguyen, and J. They are shown: how microscopy is used to detect the malaria parasite in blood samples how an Enzyme-Linked Immunosorbent Assay ELISA procedure is used to detect anti-malaria antibodies in patient samples how to interpret the results This workshop includes a presentation on malaria to provide a context for the laboratory session.
Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome. Such genes may simply not have had time to acquire dosage compensation or they could be dosage sensitive. Expression of a candidate sex-determining gene during mouse testis differentiation.
Broadening the perspective with RNA-seq.
Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. In addition, the dosage-regulated chromosome often occupies a specific nuclear compartment. Stenberg P, Larsson J. However, the effects of abnormal gene dosage are not clear in different tissues.
X-linked genes and mental functioning. Species can also switch back and forth between temperature-sensitive systems of sex determination associated with homomorphic sex chromosomes and gene-based or chromosome-based systems associated with differentiating sex chromosomes Sex-specific differences are usually ascribed to hormonal effects.
Additional student notes and teacher guide for School Assessed Coursework provided on request.